兔免疫球蛋白κ轻链的复杂同种异型由结构等位基因编码。
Complex allotypes of the rabbit immunoglobulin kappa light chains are encoded by structural alleles.
作者信息
Akimenko M A, Heidmann O, Rougeon F
出版信息
Nucleic Acids Res. 1984 Jun 11;12(11):4691-701. doi: 10.1093/nar/12.11.4691.
Abstract
We have isolated the rabbit immunoglobulin b9 Ck light chain gene and compared its nucleotide sequence with the b4, b4var , b5 and bas Ck sequences. In spite of the high number of substitutions found between the different rabbit Ck coding regions, only very few changes are silent. Furthermore, the nucleotide changes are clustered in segments which correlate with the bends and helical regions found in the tertiary structure of the Ck domain of the protein. The flanking regions present a higher degree of conservation than the coding regions. The two genomic EcoRI fragments hybridizing to a b4cDNA probe have been correlated with the two distinct loci, Ck1 and Ck2 : one encodes for the nominal b9 Ck allotype and the other contains the information for the bas Ck region. The b allotypes are true alleles which could have evolved by intergenic conversion.
摘要
我们分离出了兔免疫球蛋白b9 Ck轻链基因，并将其核苷酸序列与b4、b4var、b5和bas Ck序列进行了比较。尽管在不同的兔Ck编码区之间发现了大量的替换，但只有极少数变化是沉默的。此外，核苷酸变化集中在与蛋白质Ck结构域三级结构中的弯曲和螺旋区域相关的片段中。侧翼区域比编码区域具有更高的保守程度。与b4 cDNA探针杂交的两个基因组EcoRI片段已与两个不同的基因座Ck1和Ck2相关联：一个编码标称的b9 Ck同种异型，另一个包含bas Ck区域的信息。b同种异型是真正的等位基因，可能通过基因间转换进化而来。
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Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments.克隆的人类和小鼠κ免疫球蛋白恒定区和J区基因在功能片段上保持同源性。
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Rabbit immunoglobulin kappa genes: structure of a germline b4 allotype J-C locus and evidence for several b4-related sequences in the rabbit genome.兔免疫球蛋白κ基因：种系b4同种异型J-C基因座的结构以及兔基因组中几个与b4相关序列的证据。
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Diversity in the rabbit immunoglobulin kappa chain variable regions is amplified by nucleotide deletions and insertions at the V-J junction.兔免疫球蛋白κ链可变区的多样性通过V-J连接区的核苷酸缺失和插入而扩增。
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