Agranoff B W, Frey K A
Ann Neurol. 1984;15 Suppl:S93-7. doi: 10.1002/ana.410150717.
The use of 2-deoxyglucose for the measurement of regional cerebral glucose utilization in both animals and humans has gained widespread application. An attractive aspect of regional brain glucose metabolism is its apparent correlation with functional activity in neurons. Animal experiments suggest that this relationship is altered in brain lesions and that barbiturate anesthesia may be employed in the detection of brain regions where uncoupling of metabolism and neuronal function has occurred. A functional metabolic contrast technique is described that will permit determination of regional metabolism that is specifically attributable to neuronal activity. Areas of potential clinical application are discussed.
2-脱氧葡萄糖用于测量动物和人类大脑局部葡萄糖利用率已得到广泛应用。大脑局部葡萄糖代谢的一个吸引人的方面是它与神经元功能活动明显相关。动物实验表明，这种关系在脑损伤中会发生改变，并且巴比妥类麻醉可用于检测代谢与神经元功能解偶联的脑区。本文描述了一种功能性代谢对比技术，该技术将允许确定专门归因于神经元活动的局部代谢。文中还讨论了潜在的临床应用领域。
