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通过α1-抗胰蛋白酶表型鉴别特应性患者。

Differentiating atopic patients by means of alpha 1-antitrypsin phenotypes.

作者信息

Monteseirin Mateo F J, Conde Hernández J, Prados Castaño M, Conejero Ramos A, Romero Velasco E

出版信息

Allergol Immunopathol (Madr). 1984 Mar-Apr;12(2):111-4.

PMID:6331763
Abstract

We have divided ninety three patients in two groups, accordingly to their symptomatology. After getting each patient Alpha 1 Antitrypsin phenotype by means of Isoelectrofocusing with polyacrylamyde plates (pH 4-5), it was verified that the group without Atopic Dermatitis had more MS phenotypes in statistically significant quantities (p less than 0.005) and those with Atopic Dermatitis showed more variety of MZ phenotypes (p less than 0,025). That is why we outline that, thanks to individual conditionings a single pathogenic mechanism may preferently take place in each case leading us to conclude that the Atopy may be considered as a Syndrome more than an illness.

摘要

我们根据症状将93名患者分为两组。通过聚丙烯酰胺平板等电聚焦法(pH 4 - 5)获得每位患者的α1抗胰蛋白酶表型后,经证实,无特应性皮炎的组具有统计学意义上数量更多的MS表型(p小于0.005),而患有特应性皮炎的组表现出更多样化的MZ表型(p小于0.025)。这就是为什么我们概述,由于个体情况,单一致病机制可能在每种情况下优先发生,从而使我们得出结论,特应性可能被视为一种综合征而非一种疾病。

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