Forsgren S, Kleine B, Pobor G, Martinez C, Forni L, Coutinho A
Rev Infect Dis. 1984 Jul-Aug;6(4):524-7. doi: 10.1093/clinids/6.4.524.
Induction of resting B lymphocytes results from the interaction of competent ligands or helper cells with "triggering receptors." Subsequent clonal expansion and performance are thought to be regulated by the interaction of selective growth or maturation factors with specific receptors on induced B cells. A set of membrane molecules of B lymphocytes, including IgM, IgD, IA, IE, lipopolysaccharide receptors, receptors for Fc and C3b, and other non-immunoglobulin structures recognized by some antiidiotypic antibodies, display ligand-induced relationships. Functional studies also indicate that this group of molecules functions as a complex that regulates delivery of inductive signals, the expression of growth and maturation receptors, and/or the outcome of the interactions of these receptors with the corresponding factors.
静息B淋巴细胞的诱导是由有活性的配体或辅助细胞与“触发受体”相互作用所致。随后的克隆扩增和功能表现被认为是由选择性生长或成熟因子与诱导B细胞上的特异性受体相互作用所调控。B淋巴细胞的一组膜分子，包括IgM、IgD、IA、IE、脂多糖受体、Fc和C3b受体，以及一些抗独特型抗体识别的其他非免疫球蛋白结构，呈现出配体诱导的关系。功能研究还表明，这组分子作为一个复合体发挥作用，调节诱导信号的传递、生长和成熟受体的表达，以及这些受体与相应因子相互作用的结果。
