Villarroel F
Artif Organs. 1984 Aug;8(3):278-80. doi: 10.1111/j.1525-1594.1984.tb04290.x.
Hypersensitivity reactions in hemodialysis are rare. They have been identified only recently, since the U.S. dialysis patient population became sufficiently large for pattern recognition. These reactions might be the result of a variety of factors, including the manufacturing process and patient characteristics. Some reactions may be due to components of the dialysis system other than the dialyzer, such as the tubing sets. Data collected by the Food and Drug Administration showed that in 1982 there were 3.5 severe hypersensitivity reactions per 100,000 hollow-fiber dialyzers sold. This rate of reaction occurrence does not appear to be appreciably different from that in previous years for which information, though scant, was available. Recently, a significant reduction in the rate of the reactions seems to have occurred after some U.S. manufacturers changed their manufacturing procedures.
血液透析中的过敏反应很少见。直到最近，随着美国透析患者群体规模大到足以识别模式时，这些反应才被发现。这些反应可能是多种因素造成的，包括生产工艺和患者特征。有些反应可能是由于透析器以外的透析系统部件引起的，比如管路套件。美国食品药品监督管理局收集的数据显示，1982年每售出10万个中空纤维透析器，就有3.5例严重过敏反应。尽管此前相关信息很少，但反应发生率与往年相比似乎没有明显差异。最近，在美国一些制造商改变生产程序后，反应发生率似乎有了显著下降。
