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克罗恩病、多神经根神经炎和肌萎缩侧索硬化症中Z-DNA特异性抗体的存在。

Presence of Z-DNA specific antibodies in Crohn's disease, polyradiculoneuritis and amyotrophic lateral sclerosis.

作者信息

Allinquant B, Malfoy B, Schuller E, Leng M

出版信息

Clin Exp Immunol. 1984 Oct;58(1):29-36.

PMID:6332695
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1576953/
Abstract

Two modified polynucleotides having the Z-DNA conformation (poly [dG-dC] dien Pt and poly [dG-br5dC] . poly [dG-br5dC]) have been used for determination of antibodies to Z-DNA. Such antibodies were found in sera of patients with systemic lupus erythematosus and with Crohn's disease. They were scarcely observed in polyradiculoneuritis and in amyotrophic lateral sclerosis. In Crohn's disease sera, no antibodies to B-DNA were ever found but presence of two different families of antibodies to Z-DNA was demonstrated.

摘要

两种具有Z-DNA构象的修饰多核苷酸（聚[dG-dC]二烯铂和聚[dG-br5dC].聚[dG-br5dC]）已被用于检测抗Z-DNA抗体。在系统性红斑狼疮患者和克罗恩病患者的血清中发现了此类抗体。在多神经根神经炎和肌萎缩侧索硬化症患者的血清中几乎未观察到这些抗体。在克罗恩病患者的血清中，从未发现抗B-DNA抗体，但证实存在两个不同家族的抗Z-DNA抗体。

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本文引用的文献

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Autoantibodies to colon in rats and human ulcerative colitis: cross reactivity with Escherichia coli O:14 antigen.大鼠结肠自身抗体与人类溃疡性结肠炎：与大肠杆菌O:14抗原的交叉反应性。
Proc Soc Exp Biol Med. 1967 Jul;125(3):975-80. doi: 10.3181/00379727-125-32253.
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High-salt d(CpGpCpG), a left-handed Z' DNA double helix.高盐条件下的d（CpGpCpG），一种左手Z'型DNA双螺旋结构。
Nature. 1980 Aug 7;286(5773):567-73. doi: 10.1038/286567a0.
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The B goes to Z transition of poly(dG-dC) . poly(dG-dC) modified by some platinum derivatives.聚（dG-dC）·聚（dG-dC）经某些铂衍生物修饰后的B到Z转变。
Nucleic Acids Res. 1981 Nov 11;9(21):5659-69. doi: 10.1093/nar/9.21.5659.
4
Interaction between antibodies to Z-form deoxyribonucleic acid and double-stranded polynucleotides.Z型脱氧核糖核酸抗体与双链多核苷酸之间的相互作用。
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Serum and cerebrospinal fluid antibodies to single-stranded and double-stranded nucleic acids in neurological diseases.神经系统疾病中针对单链和双链核酸的血清及脑脊液抗体
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Antibodies specific for left-handed Z-DNA.对左手Z-DNA具有特异性的抗体。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3546-50. doi: 10.1073/pnas.78.6.3546.
7
Z-DNA-specific antibodies in human systemic lupus erythematosus.人类系统性红斑狼疮中的Z-DNA特异性抗体。
J Clin Invest. 1983 Feb;71(2):314-21. doi: 10.1172/jci110771.
8
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