Allinquant B, Giraud V, Piciotti M, Schuller E
J Neuroimmunol. 1982 Oct;3(2):77-89. doi: 10.1016/0165-5728(82)90042-x.
Two different subpopulations of IgG antibodies to nucleic acids may be demonstrated: (1) IgG directed against single-stranded (ss) nucleic acids: they are found in normal human serum and increased in sera in subacute sclerosing panencephalities, multiple sclerosis and in other neurological diseases. Absent from normal cerebrospinal fluid, they can be synthetized inside the central nervous system during these diseases. Their only common antigenic determinant seems to be the polymeric single-stranded structure. No correlation can be demonstrated between their increase in sera and their local synthesis (inside the central nervous system) and between these data and the clinical stage. These facts suggest a "non-specific" reaction and not a pathogenic mechanism. (2) IgG antibodies directed against double-stranded (ds) nucleic acids: they were detected in cerebrospinal fluid during 3 neurological diseases only, all of proved viral etiology: subacute sclerosing panencephalitis, herpes meningoencephalitis and B hepatitis polyradiculoneuritis. These antibodies are also synthetized inside the central nervous system, and are distinct from antibodies to ss nucleic acids. The mechanism of production and the signification of these antibodies remains unknown, and their scarcity in MS patients must be stressed.
可证实存在两种不同的抗核酸IgG抗体亚群：（1）针对单链（ss）核酸的IgG：它们存在于正常人血清中，在亚急性硬化性全脑炎、多发性硬化症和其他神经疾病患者的血清中含量增加。正常脑脊液中不存在此类抗体，在这些疾病中它们可在中枢神经系统内合成。它们唯一的共同抗原决定簇似乎是聚合单链结构。血清中此类抗体增加与其在中枢神经系统内的局部合成之间，以及这些数据与临床分期之间均无相关性。这些事实提示这是一种“非特异性”反应，而非致病机制。（2）针对双链（ds）核酸的IgG抗体：仅在3种神经疾病的脑脊液中检测到此类抗体，所有这些疾病均已证实由病毒引起：亚急性硬化性全脑炎、疱疹性脑膜脑炎和乙型肝炎多发性神经根神经炎。这些抗体也在中枢神经系统内合成，且与抗ss核酸抗体不同。这些抗体的产生机制及意义尚不清楚，必须强调的是它们在多发性硬化症患者中较为罕见。
