Colon-Otero G, Li C Y, Dewald G W, White W L
Mayo Clin Proc. 1984 Oct;59(10):678-82. doi: 10.1016/s0025-6196(12)62056-4.
An erythrophagocytic neoplastic infiltration of the bone marrow which resembled malignant histiocytosis was found in an elderly man who, when initially examined, had fever and cytopenias. Results of cytochemical and immunologic studies were consistent with an acute lymphocytic leukemia in which the lymphoblasts showed the simultaneous expression of lymphoid stem cell and B-cell markers. Chromosome analysis revealed an abnormal clone with a deletion of part of the long arm of chromosome 20. This case illustrates (1) the occurrence of striking erythrophagocytosis by lymphoblasts at the time of initial presentation of a patient with acute lymphocytic leukemia, (2) the fact that abnormalities of chromosome 20 can occur in patients with acute lymphocytic leukemia, and (3) the capability of lymphoid malignant lesions to show the simultaneous expression of antigens that are characteristic of different stages of lymphoid differentiation.
在一名老年男性中发现骨髓存在类似恶性组织细胞增多症的噬红细胞性肿瘤浸润，该患者初诊时伴有发热和血细胞减少。细胞化学和免疫学研究结果与急性淋巴细胞白血病相符，其中原始淋巴细胞同时表达淋巴样干细胞和B细胞标志物。染色体分析显示存在一个异常克隆，20号染色体长臂部分缺失。该病例表明：（1）急性淋巴细胞白血病患者初诊时原始淋巴细胞可出现显著的噬红细胞现象；（2）急性淋巴细胞白血病患者可发生20号染色体异常；（3）淋巴恶性病变有能力同时表达不同淋巴分化阶段特征性的抗原。
