热疗与小鼠流感免疫细胞毒性T细胞在体外的产生及活性
Hyperthermia and the generation and activity of murine influenza-immune cytotoxic T cells in vitro.
作者信息
Müllbacher A
出版信息
J Virol. 1984 Dec;52(3):928-31. doi: 10.1128/JVI.52.3.928-931.1984.
Abstract
The rate of generation of murine secondary influenza virus-immune cytotoxic T cells in vitro is enhanced under limiting dilution conditions at hyperthermal temperatures (39 versus 37 degrees C). Increased mean values of cytotoxic activity were observed in the presence as well as absence of exogenous helper factors. Elevated cytotoxic activity at 39 degrees C was observed after day 3 to day 5 of culture. The number of autoreactive cytotoxic cells observed was not greater at 39 degrees C than at 37 degrees C. Elevated temperature did not influence target cell lysis or release of isotopes from killed target cells. The results are discussed with a view to the role of fever in augmenting the cellular immune response responsible for the host defense against primary viral infection.
摘要
在高温（39℃与37℃）下的有限稀释条件下，体外鼠源继发性流感病毒免疫细胞毒性T细胞的生成速率会提高。在存在和不存在外源性辅助因子的情况下，均观察到细胞毒性活性的平均值增加。培养第3天至第5天后，在39℃观察到细胞毒性活性升高。在39℃观察到的自身反应性细胞毒性细胞数量并不比37℃时多。温度升高不影响靶细胞裂解或从死亡靶细胞中释放同位素。针对发热在增强负责宿主抵御原发性病毒感染的细胞免疫反应中的作用，对结果进行了讨论。
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