Luton J P, Baulieu F, Fumeron F, Hors J, Bricaire H
Ann Endocrinol (Paris). 1981 Jan-Mar;42(1):2-9.
HLA-A and B phenotypes were determined in 38 patients with Cushing's syndrome (29 Cushing's diseases, 9 others etiologies) and compared with those of 591 normal subjects. No significant differences was found in the HLA antigens distribution in the two groups. However the series is too small to definitely support the hypothesis of a lack of correlation with HLA. Indeed, the increased prevalence of B8 antigen in Cushing's disease (28%) as compared to that in the control group (17%), although not statistically significant, emphasizes the need for further typing of HLA-DR, particularly RDw3 which is known to be linked to D8 through desequilibrium and associated with several autoimmune diseases.
对38例库欣综合征患者（29例库欣病，9例其他病因）进行了HLA - A和B表型测定，并与591名正常受试者的表型进行比较。两组的HLA抗原分布未发现显著差异。然而，该系列样本量过小，无法明确支持与HLA缺乏相关性这一假说。实际上，库欣病中B8抗原的患病率（28%）高于对照组（17%），尽管无统计学意义，但这凸显了进一步对HLA - DR进行分型的必要性，尤其是已知通过不平衡与D8连锁并与多种自身免疫性疾病相关的RDw3。
