Treves S, Ali-Khan Z
Tropenmed Parasitol. 1984 Sep;35(3):183-8.
The kinetics and composition of leukocytic infiltrates from the biphasically growing parasite biomass and the peritonea of C57BL/6J mice infected intraperitoneally with Echinococcus multilocularis cysts were studied. During the first 6 to 8 weeks postinfection (p.i.) the larval cyst masses (LCM) grew slowly, weighted 1 g and contained 3 to 4 X 10(6) leukocytes/100 mg of LCM. Subsequently, (8 to 16 weeks p.i.) the growth of the LCM was rapid and was accompanied by 3 to 4-fold reduction in the absolute leukocyte count; monocytoid cells, neutrophils, eosinophils and T-lymphocyte significantly decreased during the progressive growth phase of the LCM. The cumulative data show a strong inverse relationship between the mean LCM weights and the absolute or relative counts of intra-LCM leukocytes. The data suggest that high concentrations of intra-LCM leukocytes, especially monocytoid cells and to a lesser degree eosinophils, regulate the growth of the LCM in C57BL/6J mice.
研究了来自双相生长的寄生虫生物质以及腹腔注射多房棘球绦虫囊肿的C57BL/6J小鼠腹膜的白细胞浸润的动力学和组成。在感染后（p.i.）的前6至8周，幼虫囊肿块（LCM）生长缓慢，重1克，每100毫克LCM含有3至4×10⁶个白细胞。随后（感染后8至16周），LCM迅速生长，并伴有白细胞绝对计数减少3至4倍；在LCM的进行性生长阶段，单核样细胞、中性粒细胞、嗜酸性粒细胞和T淋巴细胞显著减少。累积数据显示LCM平均重量与LCM内白细胞的绝对或相对计数之间存在强烈的负相关关系。数据表明，LCM内高浓度的白细胞，尤其是单核样细胞以及程度较轻的嗜酸性粒细胞，调节C57BL/6J小鼠中LCM的生长。
