多房棘球绦虫抗原可改变巨噬细胞的辅助细胞功能。
Echinococcus multilocularis antigens modify accessory cell function of macrophages.
作者信息
Rakha N K, Dixon J B, Carter S D, Craig P S, Jenkins P, Folkard S
机构信息
Department of Veterinary Pathology, Faculty of Veterinary Science, School of Tropical Medicine, University of Liverpool.
出版信息
Immunology. 1991 Dec;74(4):652-6.
Abstract
Peritoneal macrophages and splenic lymphocytes were collected from BALB/c mice, normal or previously infected with Echinococcus multilocularis. In an accessory cell function assay, peritoneal macrophages, in increasing numbers, were added to cultures of splenic lymphocytes. Cultures were stimulated by concanavalin A (Con A) or E. multilocularis culture supernatant (EMSN). Post-infection macrophages, unlike normal macrophages, suppressed Con A- and EMSN-driven lymphocyte transformation. Modification of accessory cells could also be repeatedly induced in vivo by EMSN or a single FPLC fraction of EMSN. Lymphocytes were made more sensitive to accessory cell signals following incubation with EMSN.
摘要
从正常或先前感染多房棘球绦虫的BALB/c小鼠中收集腹膜巨噬细胞和脾淋巴细胞。在辅助细胞功能测定中，将数量不断增加的腹膜巨噬细胞添加到脾淋巴细胞培养物中。培养物用刀豆蛋白A（Con A）或多房棘球绦虫培养上清液（EMSN）刺激。与正常巨噬细胞不同，感染后的巨噬细胞抑制Con A和EMSN驱动的淋巴细胞转化。EMSN或EMSN的单一FPLC组分也可在体内反复诱导辅助细胞的改变。淋巴细胞在与EMSN孵育后对辅助细胞信号更敏感。
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本文引用的文献
1
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Z Parasitenkd. 1980;62(3):241-54. doi: 10.1007/BF00926565.
2
Mitogenic effect of Coenurus cerebralis cyst fluid.脑多头蚴囊液的促有丝分裂作用。
Res Vet Sci. 1984 Jul;37(1):128.
3
4
5
Variation in the lymphocyte transformation assay. Slope analysis of cell dose-response curves.淋巴细胞转化试验中的变异。细胞剂量反应曲线的斜率分析。
J Immunol Methods. 1987 Apr 16;98(2):189-93. doi: 10.1016/0022-1759(87)90004-4.
6
7
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Biochem Biophys Res Commun. 1987 Jul 15;146(1):26-31. doi: 10.1016/0006-291x(87)90685-1.
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