Tsuge I, Ueda R, Nishida K, Namikawa R, Seto M, Maruyama T, Takamoto S, Matsuoka H, Torii S, Ota K
Clin Exp Immunol. 1984 Nov;58(2):444-52.
Five antigen systems were defined by the monoclonal antibodies (MoAb) produced against mature T cells. The antigens recognized were grouped into two categories based on the antigen distribution on T cells. (a) Tp 120 [mol. wt 120 kilodaltons (120kD)] and Tp40 (40kD), these are on most peripheral T cells, but not on any other cell lineages, i.e. pan-T antigen. (b) Ts32 (32kD), Ts145 (145kD) and TsA (not determined), these antigens are present only on certain populations of peripheral T cells, i.e., T subset antigen. Among these five, Ts145 and TsA are probably novel T cell antigens. Cell surface phenotypes of leukaemias and lymphomas were typed with these MoAb. Ia like antigen negative, null cell type acute lymphocytic leukaemia (Ia- null ALL) are Tp40+, suggesting that this type of ALL belongs to a T cell lineage. T cell ALL (T-ALL) and lymphoblastic lymphoma (LL) were both Tp40+, Ts32+, TsA+ and a half of the cases were Tp120+, but the expression of Tp40 was stronger on LL cells. Mature T cell (T2) lymphoma and adult T cell leukaemia (ATL) were Tp120+, TsA+, while Tp40 was weakly expressed on only one third of the cases. These MoAb were found to be useful to estimate the origin of various T cell malignancies.
针对成熟T细胞产生的单克隆抗体（MoAb）定义了五种抗原系统。根据T细胞上的抗原分布，所识别的抗原分为两类。（a）Tp 120[分子量120千道尔顿（120kD）]和Tp40（40kD），这些存在于大多数外周T细胞上，但不存在于任何其他细胞谱系上，即全T抗原。（b）Ts32（32kD）、Ts145（145kD）和TsA（分子量未确定），这些抗原仅存在于外周T细胞的某些群体上，即T亚群抗原。在这五种抗原中，Ts145和TsA可能是新的T细胞抗原。用这些单克隆抗体对白血病和淋巴瘤的细胞表面表型进行分型。Ia样抗原阴性的无细胞型急性淋巴细胞白血病（Ia -无ALL）为Tp40阳性，表明这种类型的ALL属于T细胞谱系。T细胞急性淋巴细胞白血病（T - ALL）和淋巴母细胞淋巴瘤（LL）均为Tp40阳性、Ts32阳性、TsA阳性，且一半病例为Tp120阳性，但LL细胞上Tp40的表达更强。成熟T细胞（T2）淋巴瘤和成人T细胞白血病（ATL）为Tp120阳性、TsA阳性，而仅三分之一的病例Tp40呈弱表达。发现这些单克隆抗体有助于评估各种T细胞恶性肿瘤的起源。
