一种人类T细胞亚群与B细胞慢性淋巴细胞白血病细胞共有的抗原。在正常和恶性淋巴细胞上的分布。
An antigen shared by a human T cell subset and B cell chronic lymphocytic leukemic cells. Distribution on normal and malignant lymphoid cells.
作者信息
Boumsell L, Coppin H, Pham D, Raynal B, Lemerle J, Dausset J, Bernard A
出版信息
J Exp Med. 1980 Jul 1;152(1):229-34. doi: 10.1084/jem.152.1.229.
Abstract
We obtained a monoclonal antibody, A50, after immunizing Biozzi's high responder strain of mice with T cell chronic lymphocytic leukemia (T-CLL) cells. A50 recognized an antigen present on the surface of B cell chronic lymphocytic leukemia cells from many patients and from cells of T lineage from any subject we tested. We could not find this antigen either on the surface of normal B cell or on other non-T cell malignancies. On T cells, this antigen was present on a subpopulation of thymus cells, and on most peripheral T cells. The antigen was present on the surface of cells from T-CLL, Sézary's disease, and a subset o T cell lymphoma. The antigen seemed to belong to a complex set of antigenic determinants that we had defined with rabbit antisera.
摘要
我们用T细胞慢性淋巴细胞白血病（T-CLL）细胞免疫Biozzi的高反应性小鼠品系后，获得了一种单克隆抗体A50。A50识别来自许多患者的B细胞慢性淋巴细胞白血病细胞表面以及我们测试的任何受试者的T系细胞表面存在的一种抗原。我们在正常B细胞表面或其他非T细胞恶性肿瘤细胞表面均未发现这种抗原。在T细胞上，这种抗原存在于胸腺细胞亚群以及大多数外周T细胞表面。该抗原存在于T-CLL、Sezary病和一部分T细胞淋巴瘤的细胞表面。该抗原似乎属于我们用兔抗血清定义的一组复杂的抗原决定簇。
相似文献
1
An antigen shared by a human T cell subset and B cell chronic lymphocytic leukemic cells. Distribution on normal and malignant lymphoid cells.一种人类T细胞亚群与B细胞慢性淋巴细胞白血病细胞共有的抗原。在正常和恶性淋巴细胞上的分布。
J Exp Med. 1980 Jul 1;152(1):229-34. doi: 10.1084/jem.152.1.229.
2
3
4
5
6
A human B lymphocyte antigen (P-76) shared by B-cell chronic lymphocytic leukemia cells and hairy cell leukemia cells.一种B细胞慢性淋巴细胞白血病细胞和毛细胞白血病细胞共有的人类B淋巴细胞抗原（P - 76）。
Blut. 1983 May;46(5):249-59. doi: 10.1007/BF00319865.
7
8
A human thymus-leukemia antigen defined by hybridoma monoclonal antibodies.一种由杂交瘤单克隆抗体定义的人类胸腺白血病抗原。
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6552-6. doi: 10.1073/pnas.76.12.6552.
9
Acute lymphocytic leukemia-associated cell membrane antigen.急性淋巴细胞白血病相关细胞膜抗原
J Natl Cancer Inst. 1978 Aug;61(2):423-9.
10
Immunologic characterization and ultrastructural correlations for 125 cases of B- and T-cell leukemias: studies of chronic and acute lymphocytic, prolymphocytic, lymphosarcoma cell and hairy cell leukemia, Sézary's syndrome, and other lymphoid leukemias.125例B细胞和T细胞白血病的免疫特征及超微结构相关性研究：慢性和急性淋巴细胞白血病、幼淋巴细胞白血病、淋巴肉瘤细胞白血病、毛细胞白血病、Sezary综合征及其他淋巴样白血病的研究
Cancer. 1981 Dec 15;48(12):2630-42. doi: 10.1002/1097-0142(19811215)48:12<2630::aid-cncr2820481215>3.0.co;2-p.
引用本文的文献
1
Uniting Disciplines to Develop Therapeutics: Targeted mRNA Lipid Nanoparticles Reprogram the Immune System to Treat Heart Disease.联合各学科开发治疗方法：靶向 mRNA 脂质纳米颗粒重编程免疫系统以治疗心脏病。
DNA Cell Biol. 2022 Jun;41(6):539-543. doi: 10.1089/dna.2022.0171. Epub 2022 Apr 20.
2
CAR T cells produced in vivo to treat cardiac injury.体内生成的 CAR T 细胞治疗心脏损伤。
Science. 2022 Jan 7;375(6576):91-96. doi: 10.1126/science.abm0594. Epub 2022 Jan 6.
3
Predominant VH1-69 IgBCR Clones Show Higher Expression of CD5 in Heterogeneous Chronic Lymphocytic Leukemia Populations.在异质性慢性淋巴细胞白血病群体中，占主导地位的VH1-69 IgBCR克隆显示出更高的CD5表达。
Front Oncol. 2021 Jun 18;11:703254. doi: 10.3389/fonc.2021.703254. eCollection 2021.
4
CD5+ B lymphocytes in systemic lupus erythematosus patients: relation to disease activity.系统性红斑狼疮患者的 CD5+ B 淋巴细胞：与疾病活动的关系。
Clin Rheumatol. 2017 Dec;36(12):2719-2726. doi: 10.1007/s10067-017-3818-z. Epub 2017 Sep 16.
5
Antibodies to the CD5 molecule in normal human immunoglobulins for therapeutic use (intravenous immunoglobulins, IVIg).用于治疗用途的正常人免疫球蛋白（静脉注射免疫球蛋白，IVIg）中CD5分子的抗体
Clin Exp Immunol. 1993 Jun;92(3):369-72. doi: 10.1111/j.1365-2249.1993.tb03407.x.
6
H-2z homozygous New Zealand mice as a model for B-cell chronic lymphocytic leukemia: elevated bcl-2 expression in CD5 B cells at premalignant and malignant stages.H-2z纯合子新西兰小鼠作为B细胞慢性淋巴细胞白血病模型：癌前和恶性阶段CD5 B细胞中bcl-2表达升高
Jpn J Cancer Res. 1993 Dec;84(12):1273-8. doi: 10.1111/j.1349-7006.1993.tb02834.x.
7
Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia.罕见的正常B淋巴细胞表现出B细胞慢性淋巴细胞白血病的特征。
J Exp Med. 1982 Feb 1;155(2):623-8. doi: 10.1084/jem.155.2.623.
8
Malignant lymphoma with dual B and T cell markers. Analysis of the neoplastic cells with monoclonal antibodies directed against T cell subsets.具有双B和T细胞标志物的恶性淋巴瘤。用针对T细胞亚群的单克隆抗体对肿瘤细胞进行分析。
J Exp Med. 1981 Nov 1;154(5):1709-14. doi: 10.1084/jem.154.5.1709.
9
The immunological classification of leukaemia based on a rapid microcytotoxicity test.基于快速微量细胞毒性试验的白血病免疫分类
Clin Exp Immunol. 1982 Jul;49(1):142-8.
10
Binding of sheep erythrocytes in chronic lymphocytic leukemias of B-cell origin.B细胞起源的慢性淋巴细胞白血病中绵羊红细胞的结合
J Clin Immunol. 1982 Oct;2(4):296-302. doi: 10.1007/BF00915070.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage.人类胸腺内分化的离散阶段：T细胞系正常胸腺细胞和白血病淋巴母细胞的分析
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1588-92. doi: 10.1073/pnas.77.3.1588.
3
Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test.同种移植的血清分型。18. 微滴淋巴细胞细胞毒性试验的改进。
Transplantation. 1968 Nov;6(8):913-27. doi: 10.1097/00007890-196811000-00006.
4
Human normal and leukemia cell surface antigens. Mouse monoclonal antibodies as probes.人类正常及白血病细胞表面抗原。以小鼠单克隆抗体作为探针。
Curr Top Microbiol Immunol. 1978;81:164-9. doi: 10.1007/978-3-642-67448-8_26.
5
Somatic cell genetics of antibody-secreting cells: studies of clonal diversification and analysis by cell fusion.抗体分泌细胞的体细胞遗传学：克隆多样化研究及细胞融合分析
Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:793-803. doi: 10.1101/sqb.1977.041.01.090.
6
A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody.一种由杂交骨髓瘤单克隆抗体所定义的人类胸腺细胞抗原。
Eur J Immunol. 1979 Mar;9(3):205-10. doi: 10.1002/eji.1830090307.
7
[The value of good Biozzi antibody-producing strains of mice for the production of monoclonal antibodies].[优良的Biozzi产抗体小鼠品系在单克隆抗体制备中的价值]
C R Seances Acad Sci D. 1979 Oct 29;289(10):723-4.
8
Subsets of malignant lymphomas in children related to the cell phenotype.儿童恶性淋巴瘤与细胞表型相关的亚群
Blood. 1979 Nov;54(5):1058-68.
9
10
Some chronic lymphocytic leukemia cells bearing surface immunoglobulins share determinants with T cells.一些带有表面免疫球蛋白的慢性淋巴细胞白血病细胞与T细胞有共同的决定簇。
Eur J Immunol. 1978 Dec;8(12):900-4. doi: 10.1002/eji.1830081214.
Zotero 插件