GM 同种异型与 HLA - B27 阳性前葡萄膜炎中强直性脊柱炎发生的关联。

Association of Gm allotypes with the occurrence of ankylosing spondylitis in HLA-B27-positive anterior uveitis.

作者信息

Kijlstra A, Linssen A, Ockhuizen T

出版信息

Am J Ophthalmol. 1984 Dec 15;98(6):732-5. doi: 10.1016/0002-9394(84)90689-5.

Abstract

We studied immunoglobulin Gm and Km allotypes in 54 patients with HLA-B27-positive anterior uveitis and in 204 healthy controls. No differences were noted between the two groups. Dividing the patients with anterior uveitis into those with ankylosing spondylitis (No. = 22) and those without it (No. = 32), produced interesting results. The Gm 1, 3, 17; 23; 5, 13, 21 phenotype was significantly (P = .007) increased in those within the ankylosing spondylitis and anterior uveitis group. Of these 22 patients, ten (45.5%) carried the Gm 1, 3, 17; 23; 5, 13, 21 phenotype compared to two of 32 (6.3%) in those with anterior uveitis alone and 33 of 204 (16.2%) normal controls. There were no significant differences between patients and controls in the frequencies of the other phenotypes tested.

摘要

我们研究了54例HLA - B27阳性前葡萄膜炎患者及204名健康对照者的免疫球蛋白Gm和Km同种异型。两组之间未发现差异。将前葡萄膜炎患者分为强直性脊柱炎患者（n = 22）和非强直性脊柱炎患者（n = 32），得出了有趣的结果。强直性脊柱炎合并前葡萄膜炎组中，Gm 1, 3, 17; 23; 5, 13, 21表型显著增加（P = .007）。在这22例患者中，10例（45.5%）携带Gm 1, 3, 17; 23; 5, 13, 21表型，而单纯前葡萄膜炎患者32例中有2例（6.3%），正常对照204例中有33例（16.2%）携带该表型。在检测的其他表型频率上，患者与对照之间无显著差异。