Whiteside M E, Barkin J S, May R G, Weiss S D, Fischl M A, MacLeod C L
Am J Trop Med Hyg. 1984 Nov;33(6):1065-72. doi: 10.4269/ajtmh.1984.33.1065.
Ten patients were identified at Jackson Memorial hospital/University of Miami Hospitals and Clinics with enteric coccidial infection due to Cryptosporidium spp. or Isospora belli. All had the acquired immunodeficiency syndrome as manifested by Kaposi's sarcoma or multiple opportunistic infections, or both. They presented with profuse diarrhea associated with weakness, anorexia, and weight loss. Routine examinations of stools for eggs and parasites as performed by the hospital laboratory were negative in all patients. Sugar flotation and modified acid fast techniques were used in the Tropical Disease Laboratory to identify oocysts of Cryptosporidium spp. in stools of seven patients. Malabsorption, characterized by a low 5-hour D-xylose and positive fecal fat, was observed in 6/6 of these patients. In three other patients Isospora belli oocysts were identified in stool specimens or via a duodenal string test. Spiramycin was the only drug found to be effective in treating patients with cryptosporidiosis. Patients with Isospora belli responded to a prolonged course of trimethoprim-sulfamethoxazole.
在杰克逊纪念医院/迈阿密大学医院及诊所确诊了10例因隐孢子虫属或贝氏等孢球虫引起的肠道球虫感染患者。所有患者均患有获得性免疫缺陷综合征，表现为卡波西肉瘤或多种机会性感染，或两者皆有。他们出现了大量腹泻，并伴有虚弱、厌食和体重减轻。医院实验室对所有患者进行的粪便虫卵和寄生虫常规检查均为阴性。热带病实验室采用蔗糖漂浮法和改良抗酸染色技术，在7例患者的粪便中鉴定出隐孢子虫属卵囊。这些患者中有6/6出现了以5小时D-木糖水平低和粪便脂肪阳性为特征的吸收不良。在另外3例患者的粪便标本中或通过十二指肠引流管试验鉴定出了贝氏等孢球虫卵囊。螺旋霉素是唯一被发现对隐孢子虫病患者有效的药物。贝氏等孢球虫感染患者对延长疗程的甲氧苄啶-磺胺甲恶唑有反应。
