新生远交系CD-1小鼠中小隐孢子虫的剂量反应
Dose response of Cryptosporidium parvum in outbred neonatal CD-1 mice.
作者信息
Finch G R, Daniels C W, Black E K, Schaefer F W, Belosevic M
机构信息
Department of Civil Engineering, University of Alberta, Edmonton, Canada.
出版信息
Appl Environ Microbiol. 1993 Nov;59(11):3661-5. doi: 10.1128/aem.59.11.3661-3665.1993.
Abstract
Cryptosporidium parvum infectivity in a neonatal CD-1 mouse model was used to determine the dose needed to infect 50% of the population. The 50% infective dose was estimated to be 79 oocysts. It was observed that a mean oral inoculum of 23 oocysts produced infection in 2 of 25 neonatal mice 7 days postinoculation. All animals became infected when the mean oral dose exceeded 310 oocysts per animal. The dose response of C. parvum was modeled with a logit dose-response model suitable for use in water disinfection studies.
摘要
在新生CD-1小鼠模型中利用微小隐孢子虫的感染性来确定感染50%群体所需的剂量。估计50%感染剂量为79个卵囊。观察到平均口服接种23个卵囊，在接种后7天，25只新生小鼠中有2只被感染。当平均口服剂量超过每只动物310个卵囊时，所有动物均被感染。微小隐孢子虫的剂量反应采用适合用于水消毒研究的logit剂量反应模型进行模拟。
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