Field L L, Stephure D K, McArthur R G
Department of Pediatrics, University of Calgary, Alberta, Canada.
Am J Hum Genet. 1991 Sep;49(3):627-34.
Despite some reports of an association between insulin-dependent diabetes mellitus (IDDM) and a BglII RFLP in the T cell receptor beta chain (TCRB) constant region, results of several recent studies, including our own, have failed to support such an association. However, we here report evidence for an IDDM-TCRB relationship which is dependent on immunoglobulin heavy-chain-region genes. We analyzed 198 unrelated diabetics and 84 normal siblings (maximum one sibling per diabetic) typed for the BglII TCRB RFLP and Gm immunoglobulin allotypes Glm(1), Glm(2), G2m(23), and G3m(5), which identify the four common Gm haplotypes. The BglIII TCRB genotype frequencies were significantly different between diabetics positive and negative for G2m(23) (P = .017) and G3m(5) (P = .021) but were not different between normal siblings positive and negative for those allotypes (P = .94 and P = .77, respectively). Thus, there were significant interactions between TCRB, Gm, and IDDM for two of the four immunoglobulin allotypes examined. We have previously reported interactions between HLA, Gm (particularly G2m(23)), and IDDM and postulate that the TCRB-Gm-IDDM and HLA-Gm-IDDM interaction effects may be functionally related.
尽管有一些报道称胰岛素依赖型糖尿病（IDDM）与T细胞受体β链（TCRB）恒定区的BglII限制性片段长度多态性（RFLP）之间存在关联，但包括我们自己的研究在内，最近的几项研究结果均未能支持这种关联。然而，我们在此报告了一种依赖于免疫球蛋白重链区基因的IDDM与TCRB的关系证据。我们分析了198名无亲缘关系的糖尿病患者和84名正常同胞（每位糖尿病患者最多一名同胞），他们被检测了BglII TCRB RFLP以及Gm免疫球蛋白同种异型Glm(1)、Glm(2)、G2m(23)和G3m(5)，这些可确定四种常见的Gm单倍型。G2m(23)阳性和阴性的糖尿病患者之间以及G3m(5)阳性和阴性的糖尿病患者之间，BglIII TCRB基因型频率存在显著差异（P = .017和P = .021），但对于这些同种异型，正常同胞之间的基因型频率并无差异（分别为P = .94和P = .77）。因此，在所检测的四种免疫球蛋白同种异型中的两种上，TCRB、Gm和IDDM之间存在显著的相互作用。我们之前曾报道过HLA、Gm（特别是G2m(23)）与IDDM之间的相互作用，并推测TCRB - Gm - IDDM和HLA - Gm - IDDM的相互作用效应可能在功能上相关。
