三种针对人类II类抗原的单克隆抗体可检测大鼠B细胞中与RT1B相关的多态性。

Three monoclonal antibodies specific for human class II antigens detect RT1B-linked polymorphisms in rat B cells.

作者信息

Ogasawara K, Takenouchi T, Kasahara M, Ikeda H, Okuyama T, Ishikawa N, Fujimoto Y, Mizuno K, Sato H, Ishida Y

出版信息

J Immunogenet. 1984 Jun-Aug;11(3-4):255-8. doi: 10.1111/j.1744-313x.1984.tb01062.x.

DOI:10.1111/j.1744-313x.1984.tb01062.x

Abstract

Three monoclonal antibodies HU-11, HU-32, and HU-33, which recognize two distinct polymorphic determinants of human class II antigens, were found to cross-react with rat B cells carrying an RT1B region-associated specificity Ba-2.6. This is the first report demonstrating that xenoimmune antibodies raised against polymorphic determinants of human class II antigens are able to detect polymorphic determinants of class II antigens in a third party species.

摘要

三种单克隆抗体HU-11、HU-32和HU-33可识别人类II类抗原的两种不同多态性决定簇，结果发现它们能与携带RT1B区域相关特异性Ba-2.6的大鼠B细胞发生交叉反应。这是首份证明针对人类II类抗原多态性决定簇产生的异种免疫抗体能够检测第三方物种中II类抗原多态性决定簇的报告。