Wagener P, Zeidler H, Eckert G, Deicher H
Z Rheumatol. 1984 Sep-Oct;43(5):253-7.
67 patients with ankylosing spondylitis (AS) were tissue-typed for HLA-A, -B and -C antigens. HLA-Bw62 was found in 6 of 13 (46%) HLA-B27 negative patients, compared to 9% in HLA-B27 positive AS (p greater than 0.01) and 10% in healthy blood donors (p greater than 0.001). HLA-Bw62, a split of the previous HLA-B15, belongs to the HLA-Bw35 CREG antigens, 11 of 13 (85%) of HLA-B27 negative patients had an HLA-Bw35 CREG antigen. The present results are interpreted as an indication of a direct involvement of the HLA-B locus in the pathogenesis of AS.
对67例强直性脊柱炎（AS）患者进行了HLA - A、- B和 - C抗原的组织分型。在13例HLA - B27阴性患者中有6例（46%）发现了HLA - Bw62，相比之下，HLA - B27阳性的AS患者中该比例为9%（p＞0.01），健康献血者中为10%（p＞0.001）。HLA - Bw62是先前HLA - B15的一个分裂型，属于HLA - Bw35 CREG抗原，13例HLA - B27阴性患者中有11例（85%）具有HLA - Bw35 CREG抗原。目前的结果被解释为表明HLA - B位点直接参与了AS的发病机制。
