Gerber N, Ambrosini G C, Böni A, Ossola A, Wagenhäuser F J, Fehr K, von Felten A
Z Rheumatol. 1977 Jul-Aug;36(7-8):219-23.
In 95 Swiss patients with classical ankylosing spondylitis (AS) the tissue antigen HLA-B27 was present in 92.6%, compared with 7.7% in healthy Swiss blood donors. Assuming the prevalence of ankylosing spondylitis in Switzerland to be 1.9 promille, the chance of a Swiss carrier of HLA-B27 to develop a classical form of AS would be only some 2.2%. For diagnostic purposes, HLA typing thus seems to be of very little value, as among the 462 000 Swiss carriers of HLA-B27 there seem to exist no more than 10 800 classical cases with clinically manifest AS. Absence of HLA-B 27 does not exclude ankylosing spondylitis, as 7.4% of the classical cases are HLA-B27-negative. However, the crudely calculated risk to develop AS is 160 times smaller compared to a carrier HLA-B27. Corner stone of the diagnosis therefore remains careful case history and radiological features of a bilateral sacroileitis of at least grade II.
在95例瑞士典型强直性脊柱炎（AS）患者中，组织抗原HLA - B27的阳性率为92.6%，而在瑞士健康献血者中该抗原阳性率为7.7%。假设瑞士强直性脊柱炎的患病率为1.9‰，那么瑞士HLA - B27携带者发展为典型AS的几率仅约为2.2%。因此，从诊断目的来看，HLA分型似乎价值不大，因为在46.2万瑞士HLA - B27携带者中，似乎只有不超过10800例典型的临床症状明显的AS病例。HLA - B27阴性并不能排除强直性脊柱炎，因为7.4%的典型病例HLA - B27呈阴性。然而，与HLA - B27携带者相比，粗略计算得出的发展为AS的风险要小160倍。因此，诊断的基石仍然是详细的病史以及至少II级双侧骶髂关节炎的放射学特征。
