Buch F, Albrektsson T, Herbst E
Biomaterials. 1984 Nov;5(6):341-6. doi: 10.1016/0142-9612(84)90032-2.
A dividable, titanium implant was inserted bilaterally in assembled form in the tibial metaphyses of adult rabbits. A titanium cathode was placed 5 mm proximal and a platinum-iridium anode 5 mm distally. The chamber on one side served as a non-stimulated control: on the other side the electrodes were connected to a constant current generator. Ten animals were treated with 5 microA, ten with 20 microA and ten with 50 microA. After three weeks the implants were removed, taken apart and the bone which had grown into two central canals of the chamber was collected for macroradiographic and computer-based numerical analysis. DC-stimulation with 50 microA did not result in any measurable increase of bone formation in the test implants compared to the controls. After stimulation with 5 or 20 microA, on the other hand, there was a statistically significant increase of osteogenesis, in spite of the fact that the electrodes were situated at some distance from the implant.
将一个可分割的钛植入物以组装形式双侧植入成年兔的胫骨干骺端。在近端5毫米处放置一个钛阴极，在远端5毫米处放置一个铂铱阳极。一侧的腔室作为非刺激对照：另一侧的电极连接到恒流发生器。十只动物接受5微安的刺激，十只接受20微安的刺激，十只接受50微安的刺激。三周后取出植入物，拆开，收集长入腔室两个中央管的骨组织，进行宏观放射照相和基于计算机的数值分析。与对照组相比，50微安的直流电刺激并未导致测试植入物中的骨形成有任何可测量的增加。另一方面，在用5或20微安刺激后，尽管电极与植入物有一定距离，但成骨有统计学上的显著增加。
