Listrom R D, Symington J M, Albrektsson T
Toronto General Hospital, Ontario, Canada.
Acta Orthop Scand. 1988 Aug;59(4):454-8. doi: 10.3109/17453678809149403.
Titanium implants containing a chamber that allowed ingrowth of bone were modified from a previous design to allow the use of oxygen microelectrodes. The modification consisted of the placement of ports in the superior surface of the implant for the insertion of oxygen electrodes into the tissue within the bone growth chamber. Forty titanium bone growth chambers were inserted into the proximal tibial metaphyses of 20 rabbits. From 2 to 20 days, oxygen tension was measured inside the chambers of 2 rabbits immediately prior to death. The oxygen tensions increased, declined, and increased again. Our results indicate that oxygen tensions fluctuate during the initial period of healing reflecting cellular changes in the callus.
含有允许骨长入的腔室的钛植入物是在先前设计的基础上进行改良的，以允许使用氧微电极。改良包括在植入物的上表面设置端口，以便将氧电极插入骨生长腔内的组织中。将40个钛骨生长腔植入20只兔子的胫骨近端干骺端。在2至20天内，在2只兔子死亡前立即测量其腔室内的氧张力。氧张力先升高，后下降，然后再次升高。我们的结果表明，在愈合初期氧张力会波动，这反映了骨痂中的细胞变化。
