作为潜在抗炎剂的N-取代聚氨酯。
N-substituted urethanes as potential antiinflammatory agents.
作者信息
Krupińska J, Piotrowicz J, Cebo E, Stypuła K, Bronisz S, Bobrański B, Stankiewicz K
出版信息
Farmaco Sci. 1985 Aug;40(8):581-8.
PMID:3876240
Abstract
Sixteen N-substituted urethanes were investigated as potential antiinflammatory agents. Most of them showed no stronger activity than phenylbutazone. The most active in the xylene hyperemia test were N,N'-dicarbethoxy-N,N'-dicyclohexyl-1,3-diaminopropane (XVI) and cyclohexyl piperidine-1-carboxylate (XIII). None of the studied compounds showed analgesic activity.
摘要
对16种N-取代的聚氨酯作为潜在的抗炎剂进行了研究。它们中的大多数显示出不比保泰松更强的活性。在二甲苯充血试验中活性最高的是N，N'-二乙氧羰基-N，N'-二环己基-1，3-二氨基丙烷（XVI）和环己基哌啶-1-羧酸酯（XIII）。所研究的化合物均未显示出镇痛活性。
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