Seltman H J, Dekker A, Van Thiel D H, Boggs D R, Starzl T E
Gastroenterology. 1983 Mar;84(3):640-3.
A patient with Budd-Chiari syndrome who underwent orthotopic liver transplantation and developed recurrent disease is described. The immediate postoperative period was complicated by multiple thrombotic episodes, followed by a period of apparent remission associated with the initiation of coumadin and persantine therapy. After discontinuation of such antithrombotic therapy in order to biopsy the liver, the patient experienced another series of clinically overt vascular thromboses and ultimately died of sepsis 15 mo posttransplantation after a prolonged and complicated terminal hospital course. At autopsy, recurrent Budd-Chiari syndrome as well as thromboses in numerous other organs was demonstrated.
本文描述了一位患有布加综合征的患者,该患者接受了原位肝移植并出现了疾病复发。术后早期出现了多次血栓形成事件,随后在开始使用华法林和潘生丁治疗后出现了一段明显缓解期。为了进行肝脏活检而停用此类抗血栓治疗后,患者经历了另一系列临床上明显的血管血栓形成,最终在移植后15个月因长期复杂的终末期住院过程死于败血症。尸检显示存在复发性布加综合征以及许多其他器官的血栓形成。