Kaijser B
Int Arch Allergy Appl Immunol. 1983;70(2):164-8. doi: 10.1159/000233316.
6 healthy adult volunteers were immunized perorally with live Escherichia coli O4K12 bacteria. The bacteria could thereafter be identified in the stools of all individuals for different periods of time. No adverse reactions were noted. 04 antibodies of the IgG class appeared in the serum of all individuals and IgM antibodies in 2 of them. The corresponding figures for K12 antibodies were 2 and 1, respectively. In saliva from the glandula parotis, secretory IgA antibodies to 04 were seen in 3, and against K12 in 1 individual. It is concluded that peroral immunization might be an alternative for induction of antibodies. Nothing is known, however, about any protective effect of these antibodies. Only a low percentage of the individuals showed K12 antibody formation. Therefore, optimal prophylactic immunization against acute pyelonephritis could be achieved by giving immunogenic K antigen, that is conjugated to a carrier, which might induce antibody formation in most individuals.
6名健康成年志愿者经口服活的大肠杆菌O4K12细菌进行免疫。此后在所有个体的粪便中可在不同时间段检测到该细菌。未观察到不良反应。所有个体血清中均出现IgG类的O4抗体，其中2人出现IgM抗体。K12抗体的相应数字分别为2人和1人。在腮腺唾液中，3人出现针对O4的分泌型IgA抗体，1人出现针对K12的分泌型IgA抗体。结论是口服免疫可能是诱导抗体产生的一种替代方法。然而，关于这些抗体的任何保护作用尚不清楚。只有低比例的个体出现K12抗体形成。因此，通过给予与载体结合的具有免疫原性的K抗原，可能在大多数个体中诱导抗体形成，从而实现针对急性肾盂肾炎的最佳预防性免疫。
