Rahier J, Wallon J, Loozen S, Lefevre A, Gepts W, Haot J
J Clin Endocrinol Metab. 1983 Mar;56(3):441-4. doi: 10.1210/jcem-56-3-441.
Pancreases from insulin-dependent diabetics (IDDM), noninsulin-dependent diabetics (NIDDM), and nondiabetic subjects were analyzed by stereological and morphometrical methods in order to determine the weight of the lobe rich in pancreatic polypeptide (PP) cells in relation to the total weight of the pancreas and the volume density of PP cells in both parts of the gland, those rich and poor in PP cells. In control subjects, neither the relative weight of the lobe rich in PP cells, nor the volume density of PP cells varied significantly with aging. In IDDM and NIDDM, the volume density of PP cells was similar to that observed in control subjects. The total weight of the pancreas was markedly decreased in IDD because of an almost selective atrophy of the lobe poor in PP cells; the relative weight of the lobe rich in PP cells was thus much higher than that in control subjects. A less marked atrophy, restricted to the lobe poor in PP cells, was also observed in NIDDM. It is suggested that PP may exert a local trophic role which protects the lobe of the pancreas rich in PP cells from atrophy in diabetic patients. The results further show that the elevated levels of PP in the plasma of elderly or diabetic subjects cannot be ascribed to a hyperplasia of PP cells.
采用体视学和形态测量学方法，对胰岛素依赖型糖尿病患者（IDDM）、非胰岛素依赖型糖尿病患者（NIDDM）和非糖尿病受试者的胰腺进行分析，以确定富含胰多肽（PP）细胞的叶的重量与胰腺总重量的关系，以及在胰腺富含PP细胞和PP细胞较少的两部分中PP细胞的体积密度。在对照受试者中，富含PP细胞的叶的相对重量以及PP细胞的体积密度均未随年龄增长而发生显著变化。在IDDM和NIDDM患者中，PP细胞的体积密度与对照受试者中观察到的相似。由于富含PP细胞的叶几乎选择性萎缩，IDDM患者的胰腺总重量明显降低；因此，富含PP细胞的叶的相对重量远高于对照受试者。在NIDDM患者中也观察到了不太明显的萎缩，且仅限于富含PP细胞的叶。提示PP可能发挥局部营养作用，保护糖尿病患者中富含PP细胞的胰腺叶免于萎缩。结果还进一步表明，老年或糖尿病受试者血浆中PP水平升高不能归因于PP细胞的增生。
