Malaisse-Lagae F, Stefan Y, Cox J, Perrelet A, Orci L
Diabetologia. 1979 Dec;17(6):361-5. doi: 10.1007/BF01236270.
Systematic sampling of human necropsy pancreases has revealed that pancreatic polypeptide (PP) cells are not distributed equally in the gland. PP-cells are the most abundant cell type in the posterior part of the pancreatic head while they are scarce or absent in the remainder of the gland. The PP-rich part of the head can be separated by blunt dissection from the pancreas as a discrete lobe. This lobe probably originates from the ventral pancreatic bud during embryogenesis. A quantitative study of the immunofluorescent endocrine cell types (insulin, glucagon, somatostatin and pancreatic polypeptide cells) in PP-rich and PP-poor regions of pancreases in 8 subjects with ages ranging from 33 fetal weeks to 80 years, showed that the proportions of the cell types were different in youngs and adults.
对人类尸检胰腺进行系统抽样研究发现，胰多肽（PP）细胞在胰腺内分布并不均匀。PP细胞是胰头后部最丰富的细胞类型，而在胰腺其余部分则稀少或不存在。胰头富含PP细胞的部分可通过钝性分离从胰腺分离出来，成为一个独立的叶。这个叶可能在胚胎发育过程中起源于腹侧胰芽。对8名年龄从33孕周至80岁的受试者的胰腺中富含PP细胞和缺乏PP细胞区域的免疫荧光内分泌细胞类型（胰岛素、胰高血糖素、生长抑素和胰多肽细胞）进行定量研究，结果显示，这些细胞类型的比例在年轻人和成年人中有所不同。
