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低强度选择性紫外线光疗。银屑病门诊治疗的一项临床试验。

Low-intensity selective UV phototherapy. A clinical trial in outpatient therapy for psoriasis.

作者信息

Paul B S, Stern R S, Parrish J A, Arndt K A

出版信息

Arch Dermatol. 1983 Feb;119(2):122-4.

PMID:6337559
Abstract

A UV source of low-intensity output with peak effective emission in the 300 to 320-nm range, termed low-intensity selective UV phototherapy (LISUP), is being advocated for home phototherapy for psoriasis. Twenty patients with plaque-type psoriasis were treated three times a week as outpatients with this unit; the results were compared with those found in a similar group of 20 outpatients treated previously three times a week with a proved and effective protocol using erythemogenic exposures to a conventional UV-B source. Emollients were the only topical agents used during therapy. Eight patients had clearing and five others showed improvement with LISUP. Eighteen patients had clearing and one showed improvement with the UV-B protocol. We found LISUP less frequently effective when used three times a week in clearing plaque-type psoriasis. Therefore, we recommend a trial of this unit before purchase by the patient.

摘要

一种低强度输出的紫外线源,其峰值有效发射波长在300至320纳米范围内,称为低强度选择性紫外线光疗法(LISUP),现被推荐用于银屑病的家庭光疗。20例斑块型银屑病患者作为门诊患者,使用该设备每周接受三次治疗;将结果与另一组20例门诊患者的结果进行比较,这组患者此前每周使用传统UV-B光源进行三次致红斑照射的有效方案进行治疗。治疗期间仅使用润肤剂作为外用药物。8例患者病情完全清除,另外5例使用LISUP治疗后有所改善。18例患者病情完全清除,1例使用UV-B方案治疗后有所改善。我们发现,每周使用三次LISUP清除斑块型银屑病的效果较差。因此,我们建议患者在购买该设备前先试用。

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Low-intensity selective UV phototherapy. A clinical trial in outpatient therapy for psoriasis.低强度选择性紫外线光疗。银屑病门诊治疗的一项临床试验。
Arch Dermatol. 1983 Feb;119(2):122-4.
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[UV-B phototherapy in psoriasis].
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Arch Dermatol Res. 2023 Dec 18;316(1):51. doi: 10.1007/s00403-023-02765-5.
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Carcinogenic effects of prolonged daily low-emission phototherapy in psoriasis.长期每日低排放光疗治疗银屑病的致癌作用。
Photodermatol Photoimmunol Photomed. 2022 Sep;38(5):442-450. doi: 10.1111/phpp.12767. Epub 2022 Jan 17.
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Home-based devices in dermatology: a systematic review of safety and efficacy.
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Arch Dermatol Res. 2022 Apr;314(3):239-246. doi: 10.1007/s00403-021-02231-0. Epub 2021 May 3.
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Improving access to home phototherapy for patients with psoriasis: current challenges and future prospects.改善银屑病患者获得家庭光疗的机会:当前挑战与未来前景。
Psoriasis (Auckl). 2016 May 18;6:55-64. doi: 10.2147/PTT.S81958. eCollection 2016.
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Home versus outpatient ultraviolet B phototherapy for mild to severe psoriasis: pragmatic multicentre randomised controlled non-inferiority trial (PLUTO study).家庭式与门诊式紫外线B光疗治疗轻至重度银屑病:实用多中心随机对照非劣效性试验(冥王星研究)
BMJ. 2009 May 7;338:b1542. doi: 10.1136/bmj.b1542.
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UVB phototherapy in an outpatient setting or at home: a pragmatic randomised single-blind trial designed to settle the discussion. The PLUTO study.门诊或家中的UVB光疗:一项旨在解决相关争议的实用随机单盲试验。PLUTO研究。
BMC Med Res Methodol. 2006 Aug 1;6:39. doi: 10.1186/1471-2288-6-39.