米安色林与阿米替林治疗重度抑郁症门诊患者的双盲对照试验。
A double-blind comparative trial with mianserin and amitriptyline in outpatients with major depressive disorders.
作者信息
Feighner J P, Jacobs R S, Jackson R E, Hendrickson G, Merideth C H, O'Meara P D
出版信息
Br J Clin Pharmacol. 1983;15 Suppl 2(Suppl 2):227S-237S. doi: 10.1111/j.1365-2125.1983.tb05870.x.
Abstract
1 A double-blind trial with parallel treatment groups was conducted to compare the safety and efficacy of mianserin with amitriptyline. 2 This was a six week trial with weekly visits. Measurements at each visit included: 21 item Hamilton Depression (HAMD) Scale. Clinical Global Impression (CGI) Scale and Treatment Emergent Symptom Scale (TESS). 3 Mianserin and amitriptyline were comparable with respect to efficacy. 4 More adverse experiences were reported by amitriptyline patients. The predominant amitriptyline adverse experiences were of the anticholinergic type; the predominant mianserin adverse experience was drowsiness/fatigue. 5 The Efficacy Index (EI), a scale combining efficacy and adverse experiences, clearly demonstrated the superiority of mianserin over amitriptyline.
摘要
- 进行了一项采用平行治疗组的双盲试验，以比较米安色林与阿米替林的安全性和疗效。2. 这是一项为期六周的试验，每周进行一次访视。每次访视时的测量指标包括：21项汉密尔顿抑郁量表（HAMD）、临床总体印象量表（CGI）和治疗中出现的症状量表（TESS）。3. 米安色林和阿米替林在疗效方面具有可比性。4. 阿米替林组报告的不良经历更多。阿米替林的主要不良经历属于抗胆碱能类型；米安色林的主要不良经历是嗜睡/疲劳。5. 疗效指数（EI），一种综合了疗效和不良经历的量表，清楚地表明了米安色林优于阿米替林。
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