雄性CBA/H小鼠中X射线诱导髓系白血病的剂量反应。
The dose-response for x-ray induction of myeloid leukaemia in male CBA/H mice.
作者信息
Mole R H, Papworth D G, Corp M J
出版信息
Br J Cancer. 1983 Feb;47(2):285-91. doi: 10.1038/bjc.1983.37.
Abstract
The form of the dose-response for induction of malignant diseases in vivo by ionizing radiation is not yet established in spite of its scientific interest and its practical importance. Considerably extended observations have confirmed that the dose-response for acute myeloid leukaemia induced in male CBA/H mice by X-ray exposure is highly curvilinear. The dose-response was well fitted by the expression aD2e-lambda D (D = dose) in agreement with induction at the cellular level in proportion to D2 over the whole dose range 0.25-6.0 Gy. The factor e-lambda D accounts for the inescapable concomitant inactivating action of the inducing irradiation. The quantitative aspects of induction of myeloid leukaemia by ionizing radiation are unlike the induction of genetic mutation or cell inactivation and suggest that interaction of two adjoining cells is an essential element in radiation leukaemogenesis.
摘要
尽管电离辐射在体内诱发恶性疾病的剂量反应形式具有科学意义和实际重要性，但尚未确定。大量扩展观察证实，雄性CBA/H小鼠经X射线照射诱发急性髓系白血病的剂量反应是高度曲线形的。剂量反应与表达式aD2e-lambda D（D =剂量）拟合良好，这与在整个0.25 - 6.0 Gy剂量范围内细胞水平上与D2成比例的诱导情况一致。因子e-lambda D解释了诱导辐射不可避免的伴随失活作用。电离辐射诱发髓系白血病的定量方面不同于基因突变或细胞失活的诱导，这表明两个相邻细胞的相互作用是辐射白血病发生的一个基本要素。
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