Law M R, Holt H A, Reeves D S, Hodson M E
J Antimicrob Chemother. 1983 Jan;11(1):83-8. doi: 10.1093/jac/11.1.83.
The clinical effectiveness of cefaclor 500 mg three times daily in the treatment of acute infective exacerbations of chronic bronchitis has been investigated by a double-blind comparison with amoxycillin in the same dose in 30 in-patients and 50 out-patients. The two antibiotics were equally effective, in terms of resolution of presenting symptoms, sputum conversion and fall in 24 h sputum weight. Side effects were infrequent. Serum and sputum concentrations of antibiotics and 24 h urinary recovery were measured in 27 patients. Concentration of both cefaclor and amoxycillin was found to be significantly lower in mucoid sputum than in purulent sputum, in contrast to earlier reports in the case of amoxycillin. No clinical advantage was apparent for patients achieving higher sputum concentration of either antibiotic.
通过对30名住院患者和50名门诊患者进行双盲比较，研究了每日三次服用500毫克头孢克洛治疗慢性支气管炎急性感染性加重的临床疗效，比较药物为相同剂量的阿莫西林。就缓解现有症状、痰液转化和24小时痰液重量下降而言，这两种抗生素同样有效。副作用很少见。对27名患者测量了抗生素的血清和痰液浓度以及24小时尿液回收率。与阿莫西林早期报告相反，发现头孢克洛和阿莫西林在黏液样痰液中的浓度明显低于脓性痰液中的浓度。对于两种抗生素痰液浓度较高的患者，未发现明显的临床优势。
