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一种与人树突状网状细胞反应的单克隆抗体的制备及其在淋巴组织免疫组织学分析中的应用。

Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue.

作者信息

Naiem M, Gerdes J, Abdulaziz Z, Stein H, Mason D Y

出版信息

J Clin Pathol. 1983 Feb;36(2):167-75. doi: 10.1136/jcp.36.2.167.

DOI:10.1136/jcp.36.2.167
PMID:6338047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC498144/
Abstract

A murine monoclonal antibody (designated R4/23) which reacts strongly with human dendritic reticulum cells (DRC) is described. Immunoperoxidase staining of tissue cryostat sections revealed that this antibody reacts strongly with DRC in lymphoid follicles (both primary and secondary), and also weakly with marginal zone splenic B cells and with some peripheral follicular mantle B lymphocytes in lymph node cortical follicles. The value of antibody R4/23 is that it allows the distribution of DRC in reactive and neoplastic lymphoid tissue to be clearly delineated. Of particular interest is the fact that all cases of follicular lymphoma of germinal centre cell origin are consistently accompanied by a proliferation of DRC, even when the neoplasm is present in non-lymphoid tissue--for example, in the kidney. In contrast, DRC in B cell lymphomas of non-germinal centre origin are partially or totally obliterated.

摘要

本文描述了一种与人类树突状网状细胞（DRC）强烈反应的鼠单克隆抗体（命名为R4/23）。组织低温切片的免疫过氧化物酶染色显示，该抗体与淋巴滤泡（初级和次级）中的DRC强烈反应，也与边缘区脾B细胞以及淋巴结皮质滤泡中的一些外周滤泡套B淋巴细胞弱反应。抗体R4/23的价值在于它能清晰描绘DRC在反应性和肿瘤性淋巴组织中的分布。特别有趣的是，所有生发中心细胞起源的滤泡性淋巴瘤病例均始终伴有DRC增殖，即使肿瘤存在于非淋巴组织中，如肾脏。相比之下，非生发中心起源的B细胞淋巴瘤中的DRC部分或完全消失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/07b53f83a0da/jclinpath00507-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/3e61f86162a5/jclinpath00507-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/3e138c4ae2bd/jclinpath00507-0051-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/adac728152c6/jclinpath00507-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/bcbb6b873a50/jclinpath00507-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/fffb6c72f670/jclinpath00507-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/1d2d2443a1d0/jclinpath00507-0050-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/494232084647/jclinpath00507-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/b8100d4ac32c/jclinpath00507-0052-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/07b53f83a0da/jclinpath00507-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/3e61f86162a5/jclinpath00507-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/3e138c4ae2bd/jclinpath00507-0051-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/adac728152c6/jclinpath00507-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/bcbb6b873a50/jclinpath00507-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/fffb6c72f670/jclinpath00507-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/1d2d2443a1d0/jclinpath00507-0050-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/494232084647/jclinpath00507-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/b8100d4ac32c/jclinpath00507-0052-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d6/498144/07b53f83a0da/jclinpath00507-0053-a.jpg

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本文引用的文献

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