Nakamura Y, Becker L E, Marks A
J Neuropathol Exp Neurol. 1983 Mar;42(2):136-45. doi: 10.1097/00005072-198303000-00003.
The distribution of S-100 proteins was examined in 98 pediatric brain neoplasms with rabbit antiserum to S-100 protein, utilizing the peroxidase-antiperoxidase (PAP) immunohistochemical technique. Positive cytoplasmic immunoreactivity was present in 22 of 24 astrocytomas, both oligodendrogliomas, eight of 13 ependymomas, all 11 choroid plexus tumors, all nine schwannomas, two of six meningiomas, and both meningeal melanomas. Mixed cytoplasmic immunoreactivity was present in both gangliogliomas, all seven craniopharyngiomas, and the only hemangioblastoma. No cytoplasmic immunoreactivity was found in primitive neuroectodermal tumors or germinoma. Nuclear immunoreactivity was present in some cases. Because of the broad spectrum of apparent immunoreactivity with S-100 antiserum, S-100 protein cannot be used as a specific marker of glial or Schwann cell tumors.
采用过氧化物酶-抗过氧化物酶（PAP）免疫组化技术，用兔抗S-100蛋白抗血清检测了98例儿童脑肿瘤中S-100蛋白的分布。24例星形细胞瘤中的22例、2例少突胶质细胞瘤、13例室管膜瘤中的8例、所有11例脉络丛肿瘤、所有9例神经鞘瘤、6例脑膜瘤中的2例以及2例脑膜黑色素瘤均呈现阳性细胞质免疫反应性。2例神经节胶质瘤、所有7例颅咽管瘤以及仅有的1例成血管细胞瘤均呈现混合细胞质免疫反应性。原始神经外胚层肿瘤或生殖细胞瘤中未发现细胞质免疫反应性。部分病例存在细胞核免疫反应性。由于S-100抗血清的明显免疫反应性范围广泛，S-100蛋白不能用作胶质细胞瘤或神经鞘细胞瘤的特异性标志物。
