血小板制品与血管前列环素生成
Platelet products and vascular PGI2 production.
作者信息
Acharya S B, MacIntyre D E
出版信息
Prostaglandins Leukot Med. 1983 Jan;10(1):73-81. doi: 10.1016/s0262-1746(83)80022-5.
The effects of products synthesized and/or secreted by activated platelets on production of PGI2 by human, rat and rabbit vascular rings were investigated. Of the platelet dense body constituents, 5HT stimulated PGI2 production by vascular tissue of all three species whereas ADP was active only on rat tissue. Of the lipids produced during platelet activation, PAF stimulated PGI2 production by vascular tissue of all three species, Lysophosphatidate was less active than PAF on rabbit and human tissue and inactive in rat tissue, and the TxA2-mimetic, U46619, was inactive on vascular tissue of all three species. It is concluded that there are species variations in the effects of agonists on vascular PGI2 production and that platelet-derived products other than platelet-derived growth factor and beta-thromboglobulin could modulate PGI2 production to regulate platelet activation in vivo.
研究了活化血小板合成和/或分泌的产物对人、大鼠和兔血管环产生前列环素（PGI2）的影响。在血小板致密体成分中，5-羟色胺（5HT）刺激所有三种物种的血管组织产生PGI2，而二磷酸腺苷（ADP）仅对大鼠组织有活性。在血小板活化过程中产生的脂质中，血小板活化因子（PAF）刺激所有三种物种的血管组织产生PGI2，溶血磷脂酸在兔和人组织上的活性低于PAF，在大鼠组织中无活性，而血栓素A2模拟物U46619对所有三种物种的血管组织均无活性。结论是，激动剂对血管PGI2产生的影响存在物种差异，并且除血小板衍生生长因子和β-血小板球蛋白外，血小板衍生产物可调节PGI2产生以在体内调节血小板活化。
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