一项双盲随机非交叉长期试验，比较0.25%噻吗洛尔滴眼液与0.5%噻吗洛尔滴眼液治疗单纯慢性青光眼的效果。
Blind randomised non-crossover long-term trial comparing topical timolol 0.25% with timolol 0.5% in the treatment of simple chronic glaucoma.
作者信息
Mills K B
出版信息
Br J Ophthalmol. 1983 Apr;67(4):216-9. doi: 10.1136/bjo.67.4.216.
Abstract
The results of a 12-month blind randomised trial comparing the intraocular pressure lowering effect of timolol 0.25% with timolol 0.5% are presented. 27% of patients (22% of eyes) required additional antiglaucoma medication after a minimum time interval of 6 months to maintain an intraocular pressure less than 23 mmHg. The mean reduction in intraocular pressure (from pretreatment values) at 12 months was 24% for eyes treated with timolol 0.25% and 19% for eyes treated with timolol 0.5%. When reductions in intraocular pressure at each follow-up interval were statistically significant (timolol 0.25% treated eyes compared with timolol 0.5% treated eyes), the significance always favoured timolol 0.25%.
摘要
本文呈现了一项为期12个月的双盲随机试验结果，该试验比较了0.25%噻吗洛尔与0.5%噻吗洛尔降低眼压的效果。27%的患者（22%的眼睛）在至少6个月的时间间隔后需要额外使用抗青光眼药物，以维持眼压低于23 mmHg。在12个月时，接受0.25%噻吗洛尔治疗的眼睛眼压平均降低（相对于治疗前值）24%，接受0.5%噻吗洛尔治疗的眼睛眼压平均降低19%。在每个随访间隔中，当眼压降低具有统计学显著性时（0.25%噻吗洛尔治疗的眼睛与0.5%噻吗洛尔治疗的眼睛相比），显著性总是有利于0.25%噻吗洛尔。
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