一项关于四种浓度的D-噻吗洛尔、0.25%的L-噻吗洛尔以及安慰剂对眼压升高患者眼压影响的研究。
A study of the effects of four concentrations of D-timolol, 0.25% L-timolol, and placebo on intraocular pressure on patients with raised intraocular pressure.
作者信息
Mills K B, Jacobs N J, Vogel R
机构信息
Manchester Royal Eye Hospital.
出版信息
Br J Ophthalmol. 1988 Jun;72(6):469-72. doi: 10.1136/bjo.72.6.469.
Abstract
The intraocular pressure lowering effect in 30 patients with raised intraocular pressure and open angles following a single application in a randomised double-masked fashion of four concentrations of D-timolol (0.25%, 0.5%, 1.0%, and 2.0%), 0.25% L-timolol, and placebo are presented. The percentage reduction in intraocular pressure after four hours following single-drop instillation range from 20% to 25% in the D-timolol group, 32% in the L-timolol group, and only 8% in the placebo group of treated eyes.
摘要
本文呈现了30例眼压升高且房角开放患者在随机双盲状态下单次应用四种浓度（0.25%、0.5%、1.0%和2.0%）的D - 噻吗洛尔、0.25% L - 噻吗洛尔及安慰剂后的眼压降低效果。单次滴注后4小时，治疗眼的眼压降低百分比在D - 噻吗洛尔组为20%至25%，L - 噻吗洛尔组为32%，而安慰剂组仅为8%。
相似文献
1
A study of the effects of four concentrations of D-timolol, 0.25% L-timolol, and placebo on intraocular pressure on patients with raised intraocular pressure.一项关于四种浓度的D-噻吗洛尔、0.25%的L-噻吗洛尔以及安慰剂对眼压升高患者眼压影响的研究。
Br J Ophthalmol. 1988 Jun;72(6):469-72. doi: 10.1136/bjo.72.6.469.
2
The effect of d-timolol on intraocular pressure in patients with ocular hypertension.d-噻吗洛尔对高眼压症患者眼压的影响。
Am J Ophthalmol. 1984 Jul 15;98(1):73-8. doi: 10.1016/0002-9394(84)90191-0.
3
Levobunolol vs timolol for open-angle glaucoma and ocular hypertension.左旋布诺洛尔与噻吗洛尔治疗开角型青光眼和高眼压症的比较
Am J Ophthalmol. 1985 Jan 15;99(1):11-7. doi: 10.1016/s0002-9394(14)75859-3.
4
Celiprolol versus timolol and placebo: a two week double-blind comparison.塞利洛尔与噻吗洛尔及安慰剂的双盲对照两周比较研究
J Ocul Pharmacol. 1987 Spring;3(1):5-10. doi: 10.1089/jop.1987.3.5.
5
6
Use of an angiotensin converting enzyme inhibitor in ocular hypertension and primary open-angle glaucoma.血管紧张素转换酶抑制剂在高眼压症和原发性开角型青光眼中的应用。
Am J Ophthalmol. 1988 Jun 15;105(6):674-7. doi: 10.1016/0002-9394(88)90063-3.
7
Additive Intraocular Pressure-Lowering Effects of the Rho Kinase Inhibitor Ripasudil (K-115) Combined With Timolol or Latanoprost: A Report of 2 Randomized Clinical Trials.Rho 激酶抑制剂 ripasudil（K-115）联合噻吗洛尔或拉坦前列素的降眼压相加作用：两项随机临床试验报告。
JAMA Ophthalmol. 2015 Jul;133(7):755-61. doi: 10.1001/jamaophthalmol.2015.0525.
8
Blind randomised non-crossover long-term trial comparing topical timolol 0.25% with timolol 0.5% in the treatment of simple chronic glaucoma.一项双盲随机非交叉长期试验，比较0.25%噻吗洛尔滴眼液与0.5%噻吗洛尔滴眼液治疗单纯慢性青光眼的效果。
Br J Ophthalmol. 1983 Apr;67(4):216-9. doi: 10.1136/bjo.67.4.216.
9
A double-masked randomized crossover study comparing the effect of latanoprost/timolol and brimonidine/timolol fixed combination on intraocular pressure and ocular blood flow in patients with primary open-angle glaucoma or ocular hypertension.一项比较拉坦前列素/噻吗洛尔和溴莫尼定/噻吗洛尔固定联合制剂对原发性开角型青光眼或高眼压症患者眼压和眼血流影响的双盲随机交叉研究。
J Ocul Pharmacol Ther. 2012 Dec;28(6):569-75. doi: 10.1089/jop.2011.0165. Epub 2012 Jul 9.
本文引用的文献
1
The effect of d-timolol on intraocular pressure in patients with ocular hypertension.d-噻吗洛尔对高眼压症患者眼压的影响。
Am J Ophthalmol. 1984 Jul 15;98(1):73-8. doi: 10.1016/0002-9394(84)90191-0.
2
Blind randomised non-crossover long-term trial comparing topical timolol 0.25% with timolol 0.5% in the treatment of simple chronic glaucoma.一项双盲随机非交叉长期试验，比较0.25%噻吗洛尔滴眼液与0.5%噻吗洛尔滴眼液治疗单纯慢性青光眼的效果。
Br J Ophthalmol. 1983 Apr;67(4):216-9. doi: 10.1136/bjo.67.4.216.
3
Effects of l- and d-timolol on cyclic AMP synthesis and intraocular pressure in water-loaded, albino and pigmented rabbits.
Invest Ophthalmol Vis Sci. 1983 Sep;24(9):1276-82.
4
R-enantiomer of timolol: a potential selective ocular antihypertensive agent.噻吗洛尔的R-对映体：一种潜在的选择性眼部抗高血压药物。
Graefes Arch Clin Exp Ophthalmol. 1984;221(5):234-8. doi: 10.1007/BF02134145.
5
-adrenergic blocking agents. 3-(3-Substituted-amino-2-hydroxypropoxy)-4-substituted-1,2,5-thiadiazoles.肾上腺素能阻断剂。3 -（3 - 取代氨基 - 2 - 羟基丙氧基）- 4 - 取代 - 1,2,5 - 噻二唑。
J Med Chem. 1972 Jun;15(6):651-5. doi: 10.1021/jm00276a022.
6
Timolol. A beta-adrenergic blocking agent for the treatment of glaucoma.
Arch Ophthalmol. 1977 Apr;95(4):601-4. doi: 10.1001/archopht.1977.04450040067008.
7
Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution.
Invest Ophthalmol. 1976 Jun;15(6):489-92.
Zotero 插件