Sauter A, Goldstein M, Engel J, Ueta K
Brain Res. 1983 Feb 7;260(2):330-3. doi: 10.1016/0006-8993(83)90691-1.
The effects of insulin on levels and turnover of catecholamines in the hypothalamus and medulla oblongata were investigated. Systemic or intraventricular administration of insulin had no effect on catecholamine levels, but increased the turnover rate of norepinephrine and epinephrine. Insulin induced a dose-related increased release of norepinephrine, epinephrine and dopamine from hypothalamic slices. These results indicate that the effects of insulin on central catecholamines are elicited by its action in the brain.
研究了胰岛素对下丘脑和延髓中儿茶酚胺水平及周转率的影响。全身或脑室内给予胰岛素对儿茶酚胺水平无影响，但增加了去甲肾上腺素和肾上腺素的周转率。胰岛素诱导下丘脑切片中去甲肾上腺素、肾上腺素和多巴胺呈剂量相关的释放增加。这些结果表明，胰岛素对中枢儿茶酚胺的作用是由其在脑内的作用所引发的。
