Klipstein F A, Engert R F, Sherman W T
Infect Immun. 1983 Feb;39(2):1000-3. doi: 10.1128/iai.39.2.1000-1003.1983.
The antigenicity of the Escherichia coli heat-labile enterotoxin was not protected against the adverse effect of gastric acidity when the toxin was given together with bicarbonate for peroral immunization to rats, but immunization with the heat-labile enterotoxin encapsulated in pH-dependent microspheres aroused the same strong degree of serum and mucosal antitoxin responses and of protection against challenge as was achieved by peroral immunization after ablation of gastric secretions by pretreatment with cimetidine.
当将大肠杆菌不耐热肠毒素与碳酸氢盐一起经口给予大鼠进行免疫时，该毒素的抗原性无法抵御胃酸的不利影响，但用pH依赖性微球包裹的不耐热肠毒素进行免疫，所引发的血清和黏膜抗毒素反应强度以及对攻击的保护程度，与用西咪替丁预处理消除胃分泌后经口免疫所达到的效果相同。
