Hill A
J Infect Dis. 1983 Mar;147(3):540-5. doi: 10.1093/infdis/147.3.540.
Mycoplasma pulmonis was frequently present in the brains of both naturally and experimentally infected rats. Recovery of mycoplasmas from the brain was more common than from the lungs, except when there was a mixed respiratory tract infection or when immunodeficient rats were used and they developed chronic respiratory disease. After intranasal infection the mycoplasmas could be recovered from the olfactory lobes before the rest of the brain. Most of the organisms were demonstrated in small groups in the sinuses and blood vessels of the brain, apparently adhering to the epithelium; a few were present in the lumen. The presence of some mycoplasmas outside the blood vessels and attached to cells in tissue showed that the blood-brain barrier can be crossed. Three days after intranasal inoculation, most organisms lined the nasal mucosa, but a few were seen close to neurons, on cells in the olfactory lobes, and in blood vessels.
肺支原体在自然感染和实验感染大鼠的脑中均频繁出现。从脑中分离出支原体比从肺中更为常见，除非存在混合性呼吸道感染，或者使用免疫缺陷大鼠且它们发展为慢性呼吸道疾病。鼻内感染后，在脑的其他部分之前，可从嗅叶中分离出支原体。大多数病原体以小群体形式出现在脑的鼻窦和血管中，显然附着在上皮细胞上；少数存在于管腔中。血管外存在一些支原体并附着于组织中的细胞，表明血脑屏障可被跨越。鼻内接种三天后，大多数病原体排列在鼻黏膜上，但在嗅叶的神经元附近、细胞上以及血管中可见少数病原体。
