Eckardt V F, Starkey G, LeCompte P, Grace N D
Leber Magen Darm. 1978 Feb;8(1):21-4.
A 31 year-old female initially presented with clinical features consistent with achalasia, which were relieved by the Heller procedure. Several years later manometric tracings excluded the diagnosis of achalasia, and suggested a motility disorder of the esophageal body. A long esophageal myotomy was performed and was followed by a marked improvement in symptoms and a normalization of the manometric tracing. Multiple histologic sections from the surgical specimen revealed the absence of ganglion cells, a feature not previously described in motor disorders other than achalasia. These findings suggest that classification of esophageal motility disorders on the basis of manometric and histologic findings might not be possible and that surgical treatment should be directed towards the predominant symptoms.
一名31岁女性最初表现出与贲门失弛缓症相符的临床特征，经海勒手术（Heller procedure）后症状缓解。几年后，食管测压描记图排除了贲门失弛缓症的诊断，并提示食管体部存在动力障碍。随后进行了长段食管肌层切开术，术后症状显著改善，食管测压描记图恢复正常。手术标本的多个组织学切片显示神经节细胞缺失，这一特征在除贲门失弛缓症以外的其他运动障碍中尚未见报道。这些发现表明，基于测压和组织学结果对食管动力障碍进行分类可能是不可能的，手术治疗应针对主要症状。
