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用小鼠F9胚胎癌细胞免疫的啮齿动物中精子发生的自身免疫损伤。

Autoimmune damage to spermatogenesis in rodents immunized with mouse F9 embryonic carcinoma cells.

作者信息

Vojtiskova M, Pokorna Z, Draber P

出版信息

Proc Natl Acad Sci U S A. 1983 Jan;80(2):459-61. doi: 10.1073/pnas.80.2.459.

DOI:10.1073/pnas.80.2.459
PMID:6340100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC393397/
Abstract

Significant inhibition of spermatogenesis and appearance of antibodies against spermatogenic cells identified by cytotoxicity and immunofluorescence reactions were observed in mice of inbred strains 129/Sv and BALB/c and in albino guinea pigs after syngeneic, allogeneic, and xenogeneic immunization with mouse F9 embryonic carcinoma cells and Freund's complete adjuvant. A similar syngeneic immunization with PYS-2 cells was ineffective. Appropriate absorption experiments confirmed the similarity between the antigens of F9 and spermatogenic cells and the absence of such a similarity with antigens of PYS-2 cells. These results support the hypothesis that the oncofetal F9 antigens represent spermatogenic differentiation antigens and thus play an essential role in spermatogenic cell differentiation.

摘要

在用小鼠F9胚胎癌细胞和弗氏完全佐剂进行同基因、异基因和异种免疫后，在近交系129/Sv和BALB/c小鼠以及白化豚鼠中观察到精子发生受到显著抑制，并且通过细胞毒性和免疫荧光反应鉴定出针对生精细胞的抗体出现。用PYS-2细胞进行类似的同基因免疫则无效。适当的吸收实验证实了F9抗原与生精细胞抗原之间的相似性，以及与PYS-2细胞抗原不存在这种相似性。这些结果支持了这样的假设，即癌胚F9抗原代表生精分化抗原，因此在生精细胞分化中起重要作用。

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Autoimmune damage to spermatogenesis in rodents immunized with mouse F9 embryonic carcinoma cells.用小鼠F9胚胎癌细胞免疫的啮齿动物中精子发生的自身免疫损伤。
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本文引用的文献

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Aspermatogenesis, anaphylaxis, and cutaneous sensitization induced in the guinea pig by homologous testicular extract.同源睾丸提取物在豚鼠中诱导的无精子症、过敏反应和皮肤致敏。
J Exp Med. 1955 Jun 1;101(6):591-604. doi: 10.1084/jem.101.6.591.
2
An isologous model of experimental autoimmune aspermato-genesis in mice.小鼠实验性自身免疫性无精子症的同源模型。
Folia Biol (Praha). 1963 Jun;9:203-9.
3
On the possible role of immunological tolerance in the prevention of autoimmune aspermatogenesis.关于免疫耐受在预防自身免疫性无精子症中的可能作用。
Folia Biol (Praha). 1962;8:207-14.
4
Induction of aspermatogenesis by passive transfer of immune sera or cells.通过免疫血清或细胞的被动转移诱导无精子发生。
Int Arch Allergy Appl Immunol. 1972;43(2):172-81. doi: 10.1159/000230835.
5
Penetration of the testicular-tubular barrier by horseradish peroxidase induced by adjuvant.佐剂诱导的辣根过氧化物酶对睾丸小管屏障的穿透作用。
Anat Rec. 1973 May;176(1):83-100. doi: 10.1002/ar.1091760106.
6
Surface antigens common to mouse cleavage embryos and primitive teratocarcinoma cells in culture.培养的小鼠卵裂期胚胎和原始性畸胎瘤细胞共有的表面抗原。
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2988-92. doi: 10.1073/pnas.70.10.2988.
7
Developmental expression of an early embryonic antigen common to mouse spermatozoa and cleavage embryos, and to human spermatozoa: its expression during spermatogenesis.一种小鼠精子、卵裂胚胎及人类精子所共有的早期胚胎抗原的发育表达：其在精子发生过程中的表达。
Dev Biol. 1976 Jun;50(2):310-20. doi: 10.1016/0012-1606(76)90154-8.
8
The cell surface antigens of mouse embryonal carcinoma cells.小鼠胚胎癌细胞的细胞表面抗原。
Biochim Biophys Acta. 1978 Sep 18;516(1):27-60. doi: 10.1016/0304-419x(78)90003-3.
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Mouse teratocarcinoma and embryonic antigens.小鼠畸胎癌和胚胎抗原。
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