Dörmer P, Dietrich M, Kern P, Horstmann R D
Blut. 1983 May;46(5):279-88. doi: 10.1007/BF00319868.
An analysis of erythroblast cell kinetics utilizing quantitative 14C-autoradiography has been performed in five cases of acute Plasmodium falciparum malaria prior to and, in four patients, 3 or 6 days after the onset of antimalarial therapy. Associated with no or only moderate anemia were changes of erythroblast morphology, a considerable shift in the frequency of red and white blood cell precursors in the bone marrow, and a reduced rate of erythroblast proliferation. There was a marked loss of polychromatic erythroblasts, which was smaller but still detectable during the therapeutic phase. The results provide some quantitative data on the extent of "parenchymal damage" of bone marrow and stress the impact of ineffective erythropoiesis and reduced rate of erythropoietic proliferation on the emergence of anemia in Plasmodium falciparum malaria.
利用定量¹⁴C-放射自显影技术对5例急性恶性疟原虫疟疾患者在抗疟治疗前以及4例患者在治疗开始后3天或6天进行了成红细胞动力学分析。伴有无贫血或仅有中度贫血的是成红细胞形态的改变、骨髓中红细胞和白细胞前体细胞频率的显著变化以及成红细胞增殖率的降低。多染性成红细胞有明显减少，在治疗阶段减少幅度较小但仍可检测到。这些结果提供了关于骨髓“实质损伤”程度的一些定量数据，并强调了无效红细胞生成和红细胞生成增殖率降低对恶性疟原虫疟疾贫血发生的影响。
