Wickramasinghe S N, Abdalla S, Weatherall D J
Scand J Haematol. 1982 Jul;29(1):83-8. doi: 10.1111/j.1600-0609.1982.tb00567.x.
The cell cycle distribution of the erythroblasts of 6 Gambian children with P. falciparum malaria was determined using the technique of combined Feulgen microspectrophotometry and 3H-thymidine autoradiography. The data showed evidence of a perturbation of erythroblast kinetics in all 6 children. The abnormalities were more marked in the children with chronic malaria than in those with acute malaria and predominantly affected the early polychromatic erythroblasts. The disturbances observed in chronic malaria included an increased proportion of cells in the G2 phase and an arrest during the progress of some cells through the S phase. The latter defect was not seen in the children with acute malaria.
采用福尔根显微分光光度法与3H-胸腺嘧啶核苷放射自显影术相结合的技术，测定了6名患恶性疟原虫疟疾的冈比亚儿童成红细胞的细胞周期分布。数据表明，所有6名儿童的成红细胞动力学均受到干扰。慢性疟疾患儿的异常情况比急性疟疾患儿更为明显，且主要影响早期多染性成红细胞。在慢性疟疾中观察到的干扰包括G2期细胞比例增加，以及一些细胞在S期进程中停滞。急性疟疾患儿未出现后一种缺陷。
