恶性疟原虫疟疾后严重贫血中的脱氧尿苷抑制试验。
The deoxyuridine suppression test in severe anaemia following Plasmodium falciparum malaria.
作者信息
Abdalla S H, Wickramasinghe S N, Weatherall D J
出版信息
Trans R Soc Trop Med Hyg. 1984;78(1):60-3. doi: 10.1016/0035-9203(84)90173-1.
Haematological studies in a group of Gambian children with severe anaemia due to Plasmodium falciparum malaria revealed marked dyserythropoietic changes in erythroblasts and evidence of increased ineffective erythropoiesis. In some cases, the bone marrow also showed a few giant metamyelocytes and ring sideroblasts. The results of deoxyuridine suppression tests indicated that these haematological disturbances were not a consequence of vitamin B12 or folate deficiency within marrow cells.
对一组因恶性疟原虫疟疾导致严重贫血的冈比亚儿童进行的血液学研究显示，成红细胞有明显的红细胞生成异常变化，且有无效红细胞生成增加的证据。在某些病例中，骨髓还出现了一些巨大晚幼粒细胞和环形铁粒幼细胞。脱氧尿苷抑制试验结果表明，这些血液学紊乱并非骨髓细胞内维生素B12或叶酸缺乏所致。
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