Abdalla S, Weatherall D J, Wickramasinghe S N, Hughes M
Br J Haematol. 1980 Oct;46(2):171-83. doi: 10.1111/j.1365-2141.1980.tb05956.x.
The haematological changes in a group of young Gambian children with P. falciparum malaria have been analysed. In children with acute infection anaemia was most marked during the period after treatment. Although many of these patients developed a positive direct Coombs test during this period of the illness it is not clear whether the anaemia which occurs after treatment has an immune basis. A second group of children showed quite different haematological findings. They appear to have a more chronic form of P. falciparum malaria infection, were profoundly anaemic at presentation, showed gross dyserythropoietic changes in their bone marrows, and had a full reticulocyte response and rise in haemoglobin after treatment. A third group of children were encountered whose haematological abnormalities were intermediate to those of the acute and chronic groups. These findings indicate that the patho-physiological mechanisms responsible for the anaemia of P. falciparum malaria are different at different stages of the illness.
对一组患有恶性疟原虫疟疾的冈比亚儿童的血液学变化进行了分析。在急性感染的儿童中，贫血在治疗后的时期最为明显。尽管许多这些患者在疾病的这一时期出现了阳性直接抗人球蛋白试验，但尚不清楚治疗后出现的贫血是否有免疫基础。第二组儿童表现出截然不同的血液学结果。他们似乎患有更慢性形式的恶性疟原虫疟疾感染，就诊时严重贫血，骨髓显示出明显的红细胞生成异常变化，治疗后网织红细胞反应完全且血红蛋白升高。遇到了第三组儿童，他们的血液学异常介于急性组和慢性组之间。这些发现表明，导致恶性疟原虫疟疾贫血的病理生理机制在疾病的不同阶段有所不同。
