Schuette W H, Chen S S, Occhipinti S J, Mujagic H S, Shackney S E
Cell Tissue Kinet. 1983 May;16(3):221-7.
An algorithm is described for the calculation of radioautographic cell grain count from measurements of total cell nuclear area and total grain area. This algorithm provides a statistical correction for grain overlap that is based on the solution to the occupancy problem in probability theory. This method permits the use of automated grain counting over a wide range of grain counts per cell, and extends the useful dynamic range of radioautographic grain counting to well over 200 grains/cell.
本文描述了一种算法，用于根据细胞核总面积和总颗粒面积的测量值计算放射自显影细胞颗粒计数。该算法基于概率论中占位问题的解决方案，对颗粒重叠进行统计校正。这种方法允许在每个细胞的颗粒计数范围很广的情况下使用自动颗粒计数，并将放射自显影颗粒计数的有效动态范围扩展到远超过200个颗粒/细胞。
