Shah S S, Johnston D, Woodcock A A, Johnson M, Geddes D M
Curr Med Res Opin. 1983;8(5):345-9. doi: 10.1185/03007998309112395.
Breathlessness, exercise tolerance, and spirometry were measured in 12 patients whose major symptom was breathlessness, secondary to severe chronic airflow limitation, during a double-blind crossover comparison of inhaled salbutamol in two dosages (200 micrograms 4-hourly and 200 micrograms 2-hourly) with placebo. Daily visual analogue scores of breathlessness, exercise tolerance and spirometry were all significantly improved with salbutamol in both dosages compared to placebo. The 2-hourly regimen was superior to the 4-hourly regimen only in terms of exercise tolerance. Walking distance had deteriorated significantly 2 hours after salbutamol on the 4-hourly regimen and was usefully increased by an extra dose of salbutamol on the 2-hourly regimen at the equivalent time, without side-effects. Salbutamol provided considerable symptomatic relief in addition to spirometric improvement in patients with chronic airflow limitation.
在一项双盲交叉比较中，对12名主要症状为呼吸困难（继发于严重慢性气流受限）的患者，测量了吸入两种剂量（每4小时200微克和每2小时200微克）沙丁胺醇与安慰剂时的呼吸困难情况、运动耐量和肺功能。与安慰剂相比，两种剂量的沙丁胺醇均使每日呼吸困难视觉模拟评分、运动耐量和肺功能得到显著改善。仅在运动耐量方面，每2小时给药方案优于每4小时给药方案。每4小时给药方案的沙丁胺醇用药2小时后步行距离显著恶化，而在相同时间，每2小时给药方案额外加用一剂沙丁胺醇可有效增加步行距离，且无副作用。除改善肺功能外，沙丁胺醇还为慢性气流受限患者提供了显著的症状缓解。
