Rosenthal M, Haskell W L, Solomon R, Widstrom A, Reaven G M
Diabetes. 1983 May;32(5):408-11. doi: 10.2337/diab.32.5.408.
The relationship between level of physical training and in vivo insulin-stimulated glucose utilization was investigated in 33 healthy nonobese subjects. Status of physical training was estimated by maximal oxygen consumption (VO2 max) during graded bicycle ergometry, and insulin action by the insulin clamp technique. Within the study population we defined a significant (r = 0.63, P less than 0.001) correlation between these two variables. This relationship was independent of age and obesity and accounted for over 40% of the variance in insulin-stimulated glucose utilization among these subjects. In addition, significant correlations existed between VO2 max and the plasma glucose (r = -0.35, P less than 0.05) and insulin (r = -0.37, P less than 0.05) responses to an oral glucose load. These results suggest that differences in level of physical training play a regulatory role in control of in vivo insulin action.
在33名健康的非肥胖受试者中，研究了体育锻炼水平与体内胰岛素刺激的葡萄糖利用之间的关系。通过分级自行车测力计运动期间的最大耗氧量（VO2 max）评估体育锻炼状况，并用胰岛素钳夹技术评估胰岛素作用。在研究人群中，我们确定这两个变量之间存在显著相关性（r = 0.63，P < 0.001）。这种关系独立于年龄和肥胖，并且在这些受试者中，胰岛素刺激的葡萄糖利用差异的40%以上可由其解释。此外，VO2 max与口服葡萄糖负荷后的血浆葡萄糖反应（r = -0.35，P < 0.05）和胰岛素反应（r = -0.37，P < 0.05）之间存在显著相关性。这些结果表明，体育锻炼水平的差异在体内胰岛素作用的控制中发挥调节作用。
