Tomoda Y, Fuma M, Miwa T, Saiki N, Ishizuka N
Gynecol Invest. 1976;7(5):280-92. doi: 10.1159/000301389.
Phytohemagglutinin-induced lymphocyte transformation (PHA-T) was depressed in pregnant women, as compared with that in nonpregnant women. Pregnancy serum had a suppressive action on PHA-T which was enhanced with the advance in pregnancy. Hydrocortisone, progesterone, alpha-fetoprotein and trophoblast-specific antigen, were demonstrated as immune suppressive factors. From these results, it was concluded that cell-mediated immunity might be reduced in pregnant women and that this reduction might be one of the causes for the maintenance of pregnancy.
与未怀孕女性相比，孕妇的植物血凝素诱导淋巴细胞转化（PHA-T）受到抑制。妊娠血清对PHA-T有抑制作用，且随着孕期进展这种抑制作用增强。氢化可的松、孕酮、甲胎蛋白和滋养层特异性抗原被证明是免疫抑制因子。从这些结果可以得出结论，孕妇的细胞介导免疫可能降低，而这种降低可能是维持妊娠的原因之一。
